In a world where poverty and ignorance are the mainstay, a disease without a cure is tearing apart the populace. The ravaging HIV/AIDS pandemic and its explosion in Africa is an example of the difficulty in controlling emerging diseases. Since its first discovery in the 1980s, HIV now affects about 5.7% of the African population between 15 and 49 years. This population represents the primary working populace in these regions, thus significantly reducing worker productivity. Lack of basic infrastructure and a social system to cope with the disease further worsens the plight of the African populace. HIV/ AIDS infection along with TB caused over 3.5 million deaths in 2004. While inclusion amongst the millennium development goals (MDGs) has increased the focus on this disease, high risk behavior still hampers its significant control. Transactional sex is a major driver of the epidemic. Worse still, the highly unstable political situation makes people more vulnerable on the African continent. Research has shown various high risk behaviors as the drivers of this epidemic in Africa. This includes; transactional sex, cross generational sex, sex for favor, multiple sexual partners, homosexuality, and injection drug users.These epidemic drivers obviously are a result of a loss of values in our cultures. Transactional sex is a result of low self esteem and a loss of moral values amongst the women in these areas who will give themselves cheaply for any financial gain or favor. Cross generational sex, also like transactional sex, is common among the population where older men have sexual pleasure with younger women for financial gain. In addition, homosexuality and injection drug users are also contributing immensely to the HIV epidemic in Africa where it previously was never known. Homosexuality rallies are gaining more prominence due to increased focus by non-governmental organizations working in these areas. Summarily, the drivers of the diseases in Africa are modifiable risks which stem from a disorientation of many. In conclusion, a turnaround of fortunes is still far away if there is no reversal of the dwindling moral values in our environment. Families as units in the population need to refocus on imbibing moral values and upholding them for a sustained reduction in the impact of HIV/AIDS in Africa.