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More Than 2,000 Drugs Now in Cancer Immunotherapy Race

December 7, 2017

(Reuters) – The race to develop new immunotherapy treatments against cancer has sparked an unprecedented explosion in the oncology drug pipeline, with more than 2,000 immune system-boosting agents now in development. The result is a scramble for patients to enrol in clinical trials, duplication of effort and the likely ultimate failure of many projects, according to experts.

Scientists Use CRISPR to Turn Genes on [in Mice] Without Editing Their DNA

December 7, 2017

(Los Angeles Times) – The revolutionary gene editing tool CRISPR-Cas9 is best-known for helping scientists edit a strand of DNA more precisely and efficiently than ever before. Now, researchers have demonstrated another use for the CRISPR complex: changing what genes are expressed without altering the genome itself. For the first time, researchers at the Salk Institute in San Diego were able to use CRISPR to activate beneficial genes in live mice suffering from muscular dystrophy, Type 1 diabetes and acute kidney injury.

Neuroscientists Just Launched an Atlas of the Developing Human Brain

December 7, 2017

(Wired) – Today, things are looking a little less mysterious. A team of researchers led by neuroscientists at UC San Francisco has spent the last five years compiling the first entries in what they hope will become an extensive atlas of gene expression in the developing human brain. The researchers describe the project in the latest issue of Science, and, with the help of researchers at UC Santa Cruz, they’ve made an interactive version of the atlas freely available online.

African Slaves Cut Open for Their Kidneys in Libya’s Burgeoning Organ Trafficking Market

December 7, 2017

(International Business Times) – The investigation into Libya’s seedy underbelly, where men and women are sold off to the highest bidder, has earned international condemnation, with demands for a swift investigation into the human rights atrocity. Now, a Ghanaian lawyer claims trafficking in the country is being used to facilitate the illegal sale of human organs and encourage a lucrative “red market”.

A New Edition of The New England Journal of Medicine Is Now Available

December 7, 2017

The New England Journal of Medicine (vol. 377, no. 8, 2017) is available online by subscription only.

Articles include:

  • “From Last to First — Could the U.S. Health Care System Become the Best in the World?” by E.C. Schneider and D. Squires
  • “The HITECH Era and the Path Forward” by V. Washington, K. DeSalvo, F. Mostashari, and D. Blumenthal
  • “The HITECH Era in Retrospect” by J.D. Halamka and M. Tripathi
  • The Changing Face of Clinical Trials: Randomized, Controlled Trials in Health Insurance Systems” by N.K. Choudhry

 

A New Edition of Clinical Ethics is Now Available

December 7, 2017

Clinical Ethics (vol. 12, no. 3, 2017) is available online by subscription only.

Articles include:

  • “The Ethical Basis for Performing Cardiopulmonary Resuscitation Only After Informed Consent in Selected Patient Groups Admitted to Hospital” by Philip Berry and Iona Heath
  • “Is Healthcare Providers’ Value-Neutrality Depending on how Controversial a Medical Intervention Is? Analysis of 10 More or Less Controversial Interventions” by Niels Lynöe, Joar Björk, and Niklas Juth
  • “Attitudes of Singapore Emergency Department Staff Towards Family Presence During Cardiopulmonary Resuscitation” by Zohar Lederman et al.
  • “‘It’s Like Sailing’ – Experiences of the Role as Facilitator During Moral Case Deliberation” by Dara Rasoal, Annica Kihlgren, and Mia Svantesson
  • “Overruling Parental Decisions in Paediatric Medicine: A Comparison of Diekema’s Harm Threshold Framework and the Zone of Parental Discretion Framework” by Vicki Xafis
  • “Beyond Individualism: Is There a Place for Relational Autonomy in Clinical Practice and Research?” by Edward S Dove et al.

 

A New Edition of JAMA Is Now Available

December 7, 2017

JAMA (vol. 318, no. 9, 2017) is available online by subscription only.

Articles include:

  • “The Nuremberg Code 70 Years Later” by Jonathan D. Moreno, Ulf Schmidt, and Steve Joffe
  • “Correcting the Medical Literature: ‘To Err Is Human, to Correct Divine'” by Stacy Christiansen and Annette Flanagin
  • “Change in Medical Exemptions From Immunization in California After Elimination of Personal Belief Exemptions” by Paul L. Delamater, Timothy F. Leslie, and Y. Tony Yang

 

A New Edition of JAMA Internal Medicine Is Now Available

December 7, 2017

JAMA Internal Medicine (vol. 177, no. 9, 2017) is available online by subscription only.

Articles include:

  • “Sharing as the Future of Medicine” by Richard Lehman
  • “Shared Decision Making—The Importance of Diagnosing Preferences” by Glyn Elwyn, Nan Cochran, and Michael Pignone
  • “Sharing Clinical Research Data—Finding the Right Balance” by Bernard Lo and Steven N. Goodman
  • “Sharing Knowledge for Health Care” by Tammy Hoffmann and Sharon Straus
  • “Sharing the Process of Diagnostic Decision Making” by John E. Brush Jr and James M. Brophy
  • “Shared Understanding With Patients” by Neal Maskrey and Andrea Gordon
  • “Sharing Experiences of Illness and Care” by Louise Locock, Richard Lehman, and Ronald M. Epstein
  • “Medical Assistance in Dying: Our Lessons Learned” by Kieran L. Quinn and Allan S. Detsky

 

A New Edition of British Medical Bulletin Is Now Available

December 7, 2017

British Medical Bulletin (vol. 123, no. 1, 2017) is available online by subscription only.

Articles include:

  • “Think Adult – Think Child! Why Should Staff Caring for Dying Adults Ask What the Death Means for Children in the Family?” by Norman Vetter
  • “Physician-Assisted Suicide—A Clean Bill of Health?” by Robert Preston

 

FDA Clears First Medical Device Accessory for Apple Watch

December 6, 2017

(Reuters) – The U.S. Food and Drug Administration on Thursday cleared a device embedded in an Apple Inc watch band that monitors a user’s heart rate, detects when something is amiss and prompts the user to take an electrocardiogram. The device, made by AliveCor, pairs the ability to take a personal 30 second electrocardiogram (EKG) with a feature that uses artificial intelligence to continuously evaluate the correlation between heart and physical activity.

Hospitals That Act as Modern-Day Debtor Prisons Deny Rights and Dignity

December 6, 2017

(STAT News) – A new Chatham House paper that I co-authored with Tom Brookes and Eloise Whitaker shows that up to hundreds of thousands of people are detained in hospitals against their will each year. Their crime? Being too poor to pay their medical bills. This phenomenon is particularly prevalent in several sub-Saharan African countries, notably Nigeria, Democratic Republic of Congo, Ghana, Cameroon, Zimbabwe, and Kenya, but there is also evidence of it in India and Indonesia. The practice of medical detentions is particularly rife in Democratic Republic of Congo. In one study of a health facility over a six-week period in 2016, 54 percent of women who had given birth and were eligible for discharge were detained for the nonpayment of user fees.

First Baby Born to U.S. Uterus Transplant Patient Raises Ethical Concerns

December 6, 2017

(NPR) – Beautiful. Pure. Natural. Medicine at its pinnacle. Those were the words of Dr. Giuliano Testa this week — the principal investigator of a clinical trial with ten women underway at Baylor University Medical Center in Dallas. He was talking about the birth of a baby boy to a mother who underwent a uterus transplant last year. It’s a first in the U.S., but in Sweden, eight babies have been born to mothers with uterus transplants. Not everyone is celebrating though.

‘Opiophobia’ Has Left Africa in Agony

December 6, 2017

(New York Times) – The cobbler’s desperate need exemplifies a problem that deeply worries palliative care experts: how they can help the 25 million people who die in agony each year in poor and middle-income countries without risking an American-style overdose epidemic abroad or triggering opposition from Western legislators and philanthropists for whom “opioid” has become a dirty word.

Stopping Opioid Addiction at One Key Source: the Hospital

December 6, 2017

(Kaiser Health News) – It may not be rocket science, but a group of surgeons at the University of Michigan’s Michigan Medicine have devised a strategy to curb the nation’s opioid epidemic — starting at their own hospital. Their findings appeared online Wednesday in the journal JAMA Surgery. Opioid addiction has been deemed a “national emergency.” It’s estimated to have claimed 64,000 lives in 2016 alone. And research shows that post-surgical patients are at an increased risk of addiction because of the medication they receive to help manage pain during recovery.

Liver Transplant Distribution Changed after Years of Debate

December 6, 2017

(Washington Post) – After years of debate, the organization that oversees the allocation of livers for transplant took steps Monday to address a long-standing geographic disparity in supply of the scarce organs. The policy approved by the Organ Procurement and Transplantation Network will make more livers available in some places — including cities such as New York and Chicago — where the shortage is more severe than it is in regions such as the southeastern United States.

I Use a Wheelchair. And Yes, I’m Your Doctor.

December 6, 2017

(New York Times) – I have been a wheelchair user since early childhood, when I sustained a spinal cord injury in a farming accident. I am now a practicing physician in the field of rehabilitation and sports medicine. In my busy outpatient clinical practice, I witness the spectrum of patients’ reactions when they find out that their doctor is, herself, disabled. Typically those first few seconds after entering an exam room — before the patient’s guard goes up — are the most informative.

A New Edition of Journal of Genetic Counseling Is Now Available

December 6, 2017

Journal of Genetic Counseling (vol. 26, no. 5, 2017) is available online by subscription only.

Articles include:

  • “A Systematic Review of Randomized Controlled Trials to Assess Outcomes of Genetic Counseling” by Barbara A. Athens et al.
  • “Characterizing Clinical Genetic Counselors’ Countertransference Experiences: an Exploratory Study” by Rebecca Reeder et al.
  • “Reasons for Declining Preconception Expanded Carrier Screening Using Genome Sequencing” by Marian J. Gilmore et al.
  • “Experiences of Pre-Implantation Genetic Diagnosis (PGD) in Sweden: a Three-Year Follow-Up of Men and Women” by Stina Järvholm, Ann Thurin-Kjellberg, and Malin Broberg
  • “Attitudes Towards Prenatal Genetic Counseling, Prenatal Genetic Testing, and Termination of Pregnancy among Southeast and East Asian Women in the United States” by Ginger J. Tsai et al.
  • “Genetic Counselors’ Perception of the Effect on Practice of Laws Restricting Abortion” by Caitlin Cooney, Laura Hercher, and Komal Bajaj
  • “Should Genetic Testing be Offered for Children? The Perspectives of Adolescents and Emerging Adults in Families with Li-Fraumeni Syndrome” by Melissa A. Alderfer et al.

 

A New Edition of The Linacre Quarterly Is Now Available

December 6, 2017

The Linacre Quarterly (vol. 84, no. 3, 2017) is available online by subscription only.

Articles include:

  • “A Guide for Religious for End-of-Life Decision Making” by Fr. James McTavish
  • “Is Medicine Losing Its Way? A Firm Foundation for Medicine as a Real
    Therapeia” by Willem Jacobus Cardinal Eijk
  • “Spiritual Care of the Sick” by Fr. Juan R. Vélez
  • “Why the Moratorium on Human-Animal Chimera Research Should Not Be
    Lifted” by Alan Moy
  • “Decision Making in Neonatal End-of-Life Scenarios in Low-Income
    Settings” by Fr. James McTavish
  • “Pulmonary Hypertension: Clinical Parameters of a Difficult Case in
    Pregnancy” by Byron C. Calhoun
  • “Moral Theological Analysis of Direct Versus Indirect Abortion” by John M. Haas
  • “Hormonal Contraception and the Development of Autoimmunity: A Review
    of the Literature” by William V. Williams

 

A New Edition of Journal of Bioethical Inquiry Is Now Available

December 6, 2017

Journal of Bioethical Inquiry (vol. 14, no. 3, 2017) is available online by subscription only.

Articles include:

  • “Stretching the Boundaries of Parental Responsibility and New Legal Guidelines for Determination of Brain Death” by Bernadette Richards and Thaddeus Mason Pope
  • “Futile Treatment—A Review” by Lenko Šari?, Ivana Prki? and Marko Juki?
  • “Are Wrongful Life Actions Threatening the Value of Human Life?” by Vera Lúcia Raposo
  • “Political Minimalism and Social Debates: The Case of Human-Enhancement Technologies” by Javier Rodríguez-Alcázar
  • “Including People with Dementia in Research: An Analysis of Australian Ethical and Legal Rules and Recommendations for Reform” by Nola M. Ries, Katie A. Thompson, and Michael Lowe
  • “Measles Vaccination is Best for Children: The Argument for Relying on Herd Immunity Fails” by Johan Christiaan Bester
  • “Medical Negligence Determinations, the “Right to Try,” and Expanded Access to Innovative Treatments” by Denise Meyerson
  • “Access to High Cost Cancer Medicines Through the Lens of an Australian Senate Inquiry—Defining the “Goods” at Stake” by Narcyz Ghinea, Miles Little, and Wendy Lipworth
  • “Exploring Vaccine Hesitancy Through an Artist–Scientist Collaboration” by Kaisu Koski and Johan Holst
  • “A Feminist Critique of Justifications for Sex Selection” by Tereza Hendl

 

A New Edition of Medico-Legal Journal Is Now Available

December 6, 2017

Medico-Legal Journal (vol. 85, no. 3, 2016) is available online by subscription only.

Articles include:

  • “Liability for Providing a Prognosis in Surgical Practice” by Alex de Costa and Amy Tam
  • “Judicial Oversight of Life-Ending Withdrawal of Assisted Nutrition and Hydration in Disorders of Consciousness in the United Kingdom: A Matter of Life and Death” by Mohamed Y Rady and Joseph L. Verheijde

 

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