(Nature) – Clinical-trial successes in the past five years suggest that a new generation of approaches has potential against several forms of cancer that resist conventional treatments. Some analysts predict that in the next ten years, immunotherapies will be used for 60% of people with advanced cancer, and will comprise a US$35-billion market. “It is kind of crazy,” says Cary Pfeffer, chief executive of Jounce Therapeutics, a company specializing in cancer immunotherapy in Cambridge, Massachusetts. “This field has become so crowded. It’s frenzied.”
(ABC News) – For a growing number of gravely ill patients running out of options, social media has become their last bastion of hope. And they’re sharing their private struggles to motivate public action. A young newlywed woman smiles for a blog photo despite obvious signs of illness: a cannula in her nose, and a bald head. A group of doctors pose in their scrubs holding signs bearing hashtags to support a sick teen. A small, shirtless boy looks out at a camera with medical tape stuck to his chest and wires sticking out of his arms as his parents snap a picture.
(Nature) – Methylation — the addition of methyl groups — tends to suppress the activity of genes. It is important in development, when it helps to guide the differentiation of embryonic stem cells into specialized tissues by orchestrating the expression of genes. But it also occurs in response to environmental changes, and these gene modifications may be inherited. They may also contribute to conditions such as cancer and type 2 diabetes.
(ABC News) – The WREX uses special elastic bands to give a child’s arm a weightless feeling. “The mechanism is similar to how a luxo lamp works to make it ‘effortless’ to move and position the head of the lamp,” says Sample. It’s a life-changing device, and one that’s benefitted hugely from 3-D printing. Producing components on site by printing them layer by layer greatly reduces the time it takes to create a WREX.
(Associated Press) – Syria’s civil war, which entered its fourth year last month, has killed more than 150,000 people, but an often overlooked figure is the number of wounded: more than 500,000, according to the International Committee of the Red Cross. An untold number of those – there’s no reliable estimate – suffered traumatic injuries that have left them physically handicapped.
(BBC) – Questions are being raised about the government’s drive to increase dementia diagnosis rates in England. Fewer than half of the estimated 670,000 people with dementia have a formal diagnosis, but ministers want to see this rise to two-thirds by 2015. But a GP writing in the British Medical Journal warned the push could lead to over-diagnosis. Meanwhile, the Alzheimer’s Society said it was being undermined by the lack of support after diagnosis.
(New York Times) – A government advisory committee on Tuesday recommended approval of a form of insulin that is inhaled rather than injected. The endorsement could lead to a new option for millions of Americans with diabetes and vindication for the persistent billionaire who spent a large amount of his fortune to develop the product.
(New York Times) – The studies are immensely expensive because the monkeys must be followed for their lifetimes and given almost the same standard of health care as human beings. But these long-running experiments are also of great importance. In laboratory mice, reducing the calories in a normal diet increases longevity by up to 40 percent, and it does so by postponing the onset of age-related diseases. The monkey studies are the most direct way of determining whether the same would be true of people.
(ProPublica) – A team of researchers at the University of Pittsburgh Medical Center examined the boards of the 50 largest drug companies by global sales (excluding three companies that were not publicly traded). The researchers found that 40 percent — 19 companies — had at least one board member who also held a leadership role at an academic medical center. Sixteen of the 17 companies based in the United States had at least one. Several had more than one.
(Nature) – The issue of genetic sequencing raises thorny issues of ethics and patient-doctor communication. If a patient chooses to opt out of testing for that recommended list of mutations does she or he really understand what that decision means? Was the physician able to make the significance of the mutations clear in a relatively short appointment? But patients are currently afforded the opportunity to opt out of life-saving procedures, so why should opting out of information about possible genetic mutations be any different? The ACMG board, which put forth this new decision, is implicitly stating that it isn’t.
(Nature) – A Hong Kong developmental biologist says he has succeeded in reproducing a method of reprogramming cells to an embryonic like state by applying mechanical stress. The surprising new development, which the author describes as a “megatwist”, took place on 1 April, the same day that the Japanese researcher who invented the method was found guilty of scientific misconduct. The new claim, however, has been greeted with scepticism.
(Medical Tourism Magazine) – Obamacare may be anything, but affordable to those cancer patients relieved that they can finally get coverage under the new healthcare reform legislature. In fact, doctors, administrators and state insurance regulators fear that rules implemented under the Affordable Care Act may actually cost these Americans access to some of the nation’s best cancer care hospitals.
(Washington Post) – Physician stress has always been a fact of life. But anecdotal reports and studies suggest a significant and rising level of discontent in recent years, especially among primary-care doctors who serve at the front lines of medicine and play a critical role in coordinating patient care.
(New York Times) – As the world’s largest maker of generic drugs, Teva Pharmaceutical Industries has been critical of brand-name manufacturers that try to block generic versions of their high-priced medicines. But Teva is now emulating its rivals, mounting an aggressive effort to stave off generic versions of Copaxone, its big-selling brand-name drug for multiple sclerosis, which is set to lose patent protection late in May.
(CNN) – An outbreak of Ebola hemorrhagic fever in West Africa has spread to Guinea’s capital and beyond its borders in an “unprecedented epidemic,” a leading aid agency reported Monday. A total of 122 patients are suspected of contracting Ebola and 78 have died, Doctors Without Borders said. Most victims have been in Guinea, but the World Health Organization reported Sunday that two deaths in Sierra Leone and one in Liberia are suspected to have been caused by the Ebola virus.
(The Telegraph) – Scientists have created living muscles which can heal themselves in an animal for the first time. They hope that the lab-grown muscle is an important step towards using it to treat injury damage in humans. Engineers measured its strength by stimulating it with electric pulses, which showed that it was more than 10 times stronger than any previous engineered muscles.
(CNN) – After a surge of sign-ups on the last day for open enrollment, Obamacare is on track to hit the White House’s original target of 7 million people signing up, a senior administration official said Tuesday. President Barack Obama will address the milestone with a statement from the Rose Garden at 4:15 p.m. ET on Tuesday.
(Nature) – A committee investigating problems in papers claiming a method to apply stress to create embryonic like cells has found the lead researcher guilty of scientific misconduct. The judgment is the latest twist — but not the final word — in the bizarre story of stimulus triggered activation of pluripotency (STAP), a method that researchers at the RIKEN Center for Developmental Biology (CDB) in Kobe, Japan, still say is able to turn ordinary mature mouse cells into cells that share embryonic stem cells’ capacity to turn into all of the body’s cells.
(The Telegraph) – The number of women giving birth over the age of fifty has more than doubled in the past five years, with three children being born to a woman in their fifties every week. The huge leap raises health fears as older women are more likely to suffer miscarriages and ectopic pregnancies while their offspring are more susceptible to genetic defects. The NHS is also being put under increased pressure as older mothers and their babies require a higher level of medical care, according to midwives.
(Medical Xpress) – Latest findings by a team of international scientists led by Singapore-based researchers reveal the genomic landscape of oesophageal squamous carcinoma. A team of scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore and National University Cancer Institute Singapore (NCIS), and their collaborators from the Cedars-Sinai Medical Centre, UCLA School of Medicine, demonstrated that a number of novel genetic defects are able to induce oesophageal cancer.